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ObjectiveTo compare the incidence of respiratory and allergic diseases in children in Xuhui District， Shanghai in 2013 and 2020， and to determine the influencing factors. MethodsAnnual average levels of air pollutants including PM2.5， PM10， O3， SO2， and NO2 were collected and described in Shanghai from 2013 to 2020. A cross-sectional survey was conducted by using a questionnaire among grade 3 to 5 students in a school in Xuhui District， Shanghai， in September 2013 and 2020， respectively. The questionnaire collected variables including living environment， daily habits， family history of respiratory and allergic diseases， and incidence of these diseases in children. Chi-square test was used to determine the difference across respiratory and allergic diseases. Logistic regression was conducted to determine the influencing factors. ResultsA total of 1 398 valid questionnaires were collected （705 in 2013 and 693 in 2020）. Compared with 2013， annual average concentrations of PM2.5， PM10， O3， SO2， and NO2 in 2020 significantly decreased. The prevalence of bronchial asthma， bronchitis， persistent cough and persistent expectoration in 2013 were significantly higher than those in 2020 （P<0.05） in Xuhui District. Multivariate analysis showed that severe air pollution， boys， parents with asthma or allergy， parents with higher educational levels， and more allergens in household were the risk factors associated with the incidence of bronchial asthma， bronchitis， allergic rhinitis and atopic eczema （P<0.05）. Parents with allergy history， high smoking frequency of family member， and more allergens in household were the risk factors associated with the incidence of persistent cough and persistent expectoration （P<0.05）. ConclusionTo 2013，2020 air pollution in Shanghai has been mitigated and prevalence of bronchial asthma and bronchitis of children has decreased. Childhood respiratory and allergic diseases are associated with indoor and outdoor environment， family medical history， and family daily habits.
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Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as a group of persistent organic pollutants among environmental endocrine disruptors, are widely used in industrial production and daily life. PFASs are widely and persistently present in the environment and organisms due to their bioaccumulation, long half-life, and low degradability properties. Published studies have proved that PFASs have immunotoxicity, endocrine toxicity, neurotoxicity, reproductive toxicity, and hepatotoxicity. At present, several epidemiological studies have been conducted on the effects of PFASs on allergic diseases, the research endpoints include asthma, allergic rhinitis, atopic dermatitis, and the expression of allergic biomarkers such as serum immunoglobulin E (IgE), but no consistent results have been observed yet. PFASs have the potential to activate several signaling pathways, including the peroxisome proliferator-activated receptor (PPAR), nuclear factor-κB (NF-κB), and JAK/STAT pathways. These mechanisms, along with increasing mast cell calcium influx and sex hormone synergistic effects, may contribute to immunomodulation in allergic diseases. At present, the exact human effect of PFASs exposure on allergic diseases and the related mechanisms are still uncertain. This review focused on the impacts of PFASs on asthma, allergic rhinitis, and atopic dermatitis and their possible mechanisms, so as to provide research ideas for the prevention, diagnosis, and treatment of allergic diseases.
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RESUMEN Introducción: La urticaria crónica es una enfermedad heterogénea delimitada de la piel caracterizada por el desarrollo de ronchas o habones. Objetivo: Determinar las características clínicas y el tratamiento farmacológico indicado en pacientes con diagnóstico de urticaria crónica. Método: Se realizó un estudio cuantitativo, prospectivo, observacional y descriptivo en un universo de 48 pacientes con diagnóstico de urticaria crónica, Hospital Militar Principal, Guinea-Bisáu, 2018-2020. Se midieron las variables: edad, sexo, tipo de urticaria, tiempo de evolución, comorbilidad y tratamiento utilizado en la primera y última consulta registrada, así como la actividad de la enfermedad. Resultados: La edad media fue de 38,52 años con predomino del sexo femenino. El tiempo medio de evolución de la enfermedad fue de 4,67 años y el 70,83 % no presentó angioedema. La urticaria crónica espontánea fue el tipo predominante. La ciproheptadina fue el tratamiento más indicado al inicio del tratamiento y al término del seguimiento su uso se incrementó. El montelukast fue el otro medicamento que incremento su uso al término del seguimiento. La actividad de la enfermedad se redujo con el tratamiento a índices reconocidos como urticaria crónica espontánea controlada. Conclusiones: La urticaria crónica en Guinea-Bisáu tiene una prevalencia y manifestaciones clínicas acorde a lo reportado a nivel mundial con esquemas de tratamiento susceptibles de modificaciones según el inicio del uso de medicamentos recomendados como ciclosporina u omalizumab.
ABSTRACT Introduction: Chronic urticaria is a heterogeneous demarcated skin disease characterized by the development of wheals or hives. Objective: Determination of the clinical characteristics and the pharmacological treatment indicated in patients diagnosed with chronic urticaria. Method: A quantitative, prospective, observational and descriptive study was conducted in a total of 48 patients (the universe) diagnosed with chronic urticaria, Main Military Hospital, Guinea-Bissau, 2018-2020. The following variables were used: age, sex, type of urticaria, time of evolution, comorbidity and treatment used in the first and last recorded consultation, as well as disease activity. Results: The mean age was 38.52 years with a female predominance. The mean time of evolution of the disease was 4.67 years and 70.83% did not present angioedema. Chronic spontaneous urticaria was the predominant type. cyproheptadine was the treatment most indicated to be used at baseline and at the end of treatment follow-up its use increased. montelukast was the other drug that increased its use at the end of follow-up. With the treatment used disease activity was reduced up to rates recognized as controlled chronic spontaneous urticaria. Conclusions: Chronic urticaria in Guinea-Bissau has prevalence and clinical manifestations in line with those reported worldwide, with treatment regimens susceptible to modifications depending on the early use of recommended drugs such as cyclosporine or omalizumab.
RESUMO Introdução: A urticária crônica é uma doença heterogênea delimitada da pele caracterizada pelo desenvolvimento de urticária ou urticária. Objetivo: Determinar as características clínicas e o tratamento farmacológico indicado em pacientes com diagnóstico de urticária crônica. Método: Estudo quantitativo, prospectivo, observacional e descritivo realizado em um universo de 48 pacientes com diagnóstico de urticária crônica, Hospital Militar Principal, Guiné-Bissau, 2018-2020. As variáveis foram mensuradas: idade, sexo, tipo de urticária, tempo de evolução, comorbidade e tratamento utilizado na primeira e última consulta registrada, bem como a atividade da doença. Resultados: A média de idade foi de 38,52 anos com predomínio do sexo feminino. O tempo médio de evolução da doença foi de 4,67 anos e 70,83% não apresentavam angioedema. A urticária crônica espontânea foi o tipo predominante. A ciproeptadina foi o tratamento mais indicado no início do tratamento e ao final do seguimento seu uso aumentou. O montelucaste foi a outra droga que aumentou seu uso ao final do seguimento. A atividade da doença foi reduzida com o tratamento para taxas reconhecidas como urticária crônica espontânea controlada. Conclusões: A urticária crônica na Guiné-Bissau tem prevalência e manifestações clínicas compatíveis com a relatada mundialmente, com esquemas de tratamento que podem ser modificados dependendo do início do uso de medicamentos recomendados como ciclosporina ou omalizumabe.
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Objective:To guide the improvement of related nursing strategies by observing the therapeutic effect of omalizumab on patients with allergic diseases and summarizing the nursing work.Methods:Collected the medical history, the total serum IgE level before the start of treatment, clinical symptoms Visual Analogue Scale (VAS) questionnaire, and the Patient Global Impression of Change (PGIC) after treatment of 108 patients with allergic diseases who received omalizumab in the Allergy Department of Beijing Tongren Hospital from October 2018 to September 2020. The clinical efficacy was mainly evaluated based on the VAS scores of lung and nasal symptoms before and after treatment.Results:Omalizumab injection could significantly improve nasal and pulmonary symptoms whether the injection of omalizumab was sufficient or not ( P<0.05) , but there was o significant difference between the two ( P>0.05). The number of injections was positively correlated with the improvement of shortness of breath/dyspnea ( r=0.225, P<0.05) . The PGIC score of patients with sufficient injection was 3.0(2.0, 3.0) points, and that of patients with insufficient injection was 2.0(2.0, 3.0) points, the difference was not statistically significant ( Z=-0.73, P>0.05). Conclusions:Injection of omalizumab can significantly improve the nasal and pulmonary symptoms of patients. Effective nursing intervention strategies can improve patient compliance,so as to ensure that standardized treatment is of great significance to the improvement of patients′ clinical symptoms.
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Objective To investigate the prevalence of allergic and infectious diseases in children， and to assess the influence of indoor and outdoor environmental factors on these two common diseases in children. Methods A questionnaire was used to investigate the prevalence of allergic and infectious diseases in 140 children of 7 years old in Laizhou Bay， Shandong Province. Logistic regression was used to analyze the associations between indoor and outdoor environmental factors and children’s allergic and infectious diseases， respectively. Results The prevalence of previous eczema and other allergic diseases for the past year in children was 37.9% and 15.0%， respectively， and the prevalence of infectious diseases for the past year was 35.7%. As for allergic diseases， eye irritation due to outdoor air （ OR =2.977； 95% CI ： 1.407‒6.296） and nose irritation due to outdoor air （ OR =5.147； 95% CI ： 1.272‒20.827） were the risk factors for previous eczema in children. Indoor musty taste increased the risks of urticaria （ OR =4.306； 95% CI ： 1.062‒17.454） and previous eczema （ OR =3.853； 95% CI ： 1.080‒13.743）. The use of cockroach killers indoors increased the risk of rhinitis （ OR =6.102； 95% CI ：1.297‒28.697）. As for infectious diseases， having outdoor pollution sources increased the risk of gastrointestinal infection （ OR =4.937； 95% CI ： 1.050‒23.216）， and the use of mosquito coils and clothing mothproofing agents increased the risks of respiratory （ OR =6.333； 95% CI ： 1.397‒28.714） and gastrointestinal infections （ OR =3.218； 95% CI ： 1.074‒9.644）， respectively. However， we did not find associations between indoor passive smoking and allergic or infectious diseases. Conclusion Except outdoor passive smoking， all the other indoor and outdoor environmental factors increase the risks of children’s allergies and infectious diseases.
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Objective To investigate the prevalence of allergic and infectious diseases in children， and to assess the influence of indoor and outdoor environmental factors on these two common diseases in children. Methods A questionnaire was used to investigate the prevalence of allergic and infectious diseases in 140 children of 7 years old in Laizhou Bay， Shandong Province. Logistic regression was used to analyze the associations between indoor and outdoor environmental factors and children’s allergic and infectious diseases， respectively. Results The prevalence of previous eczema and other allergic diseases for the past year in children was 37.9% and 15.0%， respectively， and the prevalence of infectious diseases for the past year was 35.7%. As for allergic diseases， eye irritation due to outdoor air （ OR =2.977； 95% CI ： 1.407‒6.296） and nose irritation due to outdoor air （ OR =5.147； 95% CI ： 1.272‒20.827） were the risk factors for previous eczema in children. Indoor musty taste increased the risks of urticaria （ OR =4.306； 95% CI ： 1.062‒17.454） and previous eczema （ OR =3.853； 95% CI ： 1.080‒13.743）. The use of cockroach killers indoors increased the risk of rhinitis （ OR =6.102； 95% CI ：1.297‒28.697）. As for infectious diseases， having outdoor pollution sources increased the risk of gastrointestinal infection （ OR =4.937； 95% CI ： 1.050‒23.216）， and the use of mosquito coils and clothing mothproofing agents increased the risks of respiratory （ OR =6.333； 95% CI ： 1.397‒28.714） and gastrointestinal infections （ OR =3.218； 95% CI ： 1.074‒9.644）， respectively. However， we did not find associations between indoor passive smoking and allergic or infectious diseases. Conclusion Except outdoor passive smoking， all the other indoor and outdoor environmental factors increase the risks of children’s allergies and infectious diseases.
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RESUMEN Introducción: el asma es una enfermedad inflamatoria crónica de las vías aéreas, caracterizada por crisis de tos, dificultad respiratoria y sibilancias, usualmente reversibles, pero a veces graves y ocasionalmente fatales. Objetivo: describir las características clínicas- epidemiológicas del asma bronquial en niños de 5 a 14 años, ingresados en el Servicio de Respiratorio del Hospital infantil de Bayamo, desde enero 2017 hasta junio 2019. Métodos: el universo estuvo constituido por 273 pacientes ingresados por asma en dicho servicio y la muestra después de aplicados los criterios de inclusión y exclusión quedó conformada por 255 niños. El procesamiento de los datos se realizó mediante el programa EPIDAT versión 3.1, como procesador de texto, el programa Microsoft Word versión 6.0. Resultados: predominó el grupo de 5 a 9 años (78 %) y el sexo masculino (54,1%). Las crisis se desencadenaron con mayor frecuencia en el cuarto y primer trimestre. Los factores de riesgo fueron los antecedentes familiares de atopia y la exposición a los alérgenos (100%), Predominó el asma moderada persistente (43,9%) y la intermitente (32,1%). Conclusiones: los varones de 5 a 9 años fueron los más afectados durante el cuarto y primer trimestre del año. La atopia familiar y exposición alérgenos estuvieron presentes en todos los casos y la mayoría presentó asma moderada persistente seguida por intermitente.
ABSTRACT Introduction: asthma is a chronic inflammatory disease of the airways, characterized by coughing, respiratory distress and wheezing, usually reversible, but sometimes serious and occasionally fatal. Objective: to describe the clinical-epidemiological characteristics of bronchial asthma in children aged 5 to 14, admitted to the Respiratory Service of the Children's Hospital of Bayamo, from January 2017 to June 2019. Methods: the universe consisted of 273 patients admitted for asthma in said service and the sample after applying the inclusion and exclusion criteria was made up of 255 children. The data was processed using the EPIDAT version 3.1 program, as a word processor, the Microsoft Word version 6.0 program. Results: the group aged 5 to 9 years (78%) and the male sex (54.1%) predominated. The crises were triggered with greater frequency in the fourth and first trimesters. Risk factors were family history of atopy and exposure to allergens (100%), persistent moderate asthma (43.9%) and intermittent asthma (32.1%). Conclusions: men aged 5 to 9 were the most affected during the fourth and first trimesters of the year. Family atopy and allergen exposure were present in all cases and most presented persistent moderate asthma followed by intermittent.
RESUMO Introdução: a asma é uma doença inflamatória crônica das vias aéreas, caracterizada por crises de tosse, dificuldade respiratória e sibilância, geralmente reversível, mas às vezes grave e ocasionalmente fatal. Objetivo: descrever as características clínico-epidemiológicas da asma brônquica em crianças de 5 a 14 anos, internadas no Serviço Respiratório do Hospital Infantil de Bayamo, no período de janeiro de 2017 a junho de 2019. Métodos: o universo foi constituído por 273 pacientes internados por asma no referido serviço e a amostra após aplicação dos critérios de inclusão e exclusão foi composta por 255 crianças. O processamento dos dados foi realizado no programa EPIDAT versão 3.1, como processador de texto, o programa Microsoft Word versão 6.0. Resultados: predominou a faixa etária de 5 a 9 anos (78%) e o sexo masculino (54,1%). As crises foram desencadeadas com maior frequência no quarto e primeiro trimestres. Os fatores de risco foram história familiar de atopia e exposição a alérgenos (100%), com predomínio de asma moderada persistente (43,9%) e intermitente (32,1%). Conclusões: homens de 5 a 9 anos foram os mais acometidos durante o quarto e primeiro trimestres do ano. Atopia familiar e exposição a alérgenos estavam presentes em todos os casos e a maioria tinha asma moderada persistente seguida de asma intermitente.
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Objective:To investigate the safety and consistency of domestic inhaled allergen extracts in the diagnosis of allergic diseases in children.Methods:Nine thousand five hundred and sixty-three children diagnosed with allergic diseases from September 2018 to June 2020 in Children′s Hospital Affiliated to Capital Institute of Pedia-trics were selected in this study, and all of them were subjected to skin prick test(SPT), and 415 of them were subjected to serum specific IgE (sIgE) test at the same time.The adverse events during SPT were recorded and the consistency of the results between SPT and sIgE test was analyzed.Results:There were 14 cases with adverse events in 9 563 patients, and the overall incidence was 0.15%.The incidence of adverse events was 0.07% (2/2 581 cases) in the 1-5 years old group, 0.19% (12/6 197 cases) in the 6-11 years old and 0 in the 12-17 years old group.The severity of all these events was grade Ⅰ.Out of the 14 cases with adverse events, only 1 case was considered to be related to allergen preparations, with the incidence being 0.01% (1/9 563 cases). The Kappa index showed that the results of dermatophagoides pteronyssinus, dermatophagoides farinae, alternaria and artemisia measured by SPT and sIgE were almost the same.There was high consistency between tree pollens and ragweed ( P<0.01), and moderate consistency between aspergillus fumigatus ( P<0.01). When the results of sIgE were used as the diagnostic criteria, the Youden index for the results of SPT ranged from 0.76 to 0.89, with aspergillus fumigatus (0.76) and tree pollens mixture (0.79) as the lowest.The positive likelihood ratio for most of the inhaled allergens was more than 10 except for tree pollens mixture (7.12) and dermatophagoides farinae (9.10). The negative likelihood ratio for most of the inhaled allergens was less than or equal to 0.1 except for aspergillus fumigatus (0.19). Conclusions:The domestic inhaled allergen extracts had high safety in the clinical application of SPT, and their results of SPT had good consistency with those of serum sIgE, which was conducive to the diagnosis and evaluation of allergic diseases in children.
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@#<p style="text-align: justify;"><strong>BACKGROUND:</strong> Over the last decades, the hypothesis that an allergic response could lead to the development of attention-deficit/hyperactivity disorder (ADHD) was raised and clinical studies investigated the co-existence of both. These studies had shown that allergic diseases and neurobehavioral disorders were concurrent and could be associated with genetic factors, neuroimmunity and microbial dysbiosis. To date, this was the first study in the Philippines to evaluate the prevalence and association of allergic diseases, its severity and ADHD symptoms.</p><p style="text-align: justify;"><strong>OBJECTIVE:</strong> The objective of this study was to determine the association of allergic diseases and ADHD symptoms among children aged 6-12 years based on parental report using the Filipino version of the Vanderbilt ADHD Parent Rating Scale.</p><p style="text-align: justify;"><strong>METHODS:</strong> School-aged children between 6 and 12 years with physician diagnosed allergies (bronchial asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, drug allergy, food allergy and/or acute or chronic urticaria) were randomly selected. Skin prick test (SPT) to aeroallergens was done. The parents completed the Filipino version of the Vanderbilt ADHD Diagnostic Parent Rating Scale (VADPRS), a screening tool for ADHD.</p><p style="text-align: justify;"><strong>RESULTS:</strong> Among the 415 patients, 135 (32.5%) of them screened positive for ADHD symptoms. Upon assessment of the Vanderbilt parent rating subscale responses, 13.49% of the children were categorized as predominantly inattentive subtype, 6.02% as predominantly hyperactive/impulsive subtype and 13.01% as combined inattention/hyperactivity. Three hundred and seventy six (91%) children were diagnosed with asthma. Among these asthmatics, 119 (32%) had ADHD symptoms with the following subtypes - predominantly inattentive subtype (13.56%), predominantly hyperactive/impulsive subtype (5.05%) and combined inattention/hyperactivity (13.03%). Combined inattention/hyperactivity subtype had a significant proportion of severe asthmatics, as compared to mild or moderate asthma (p value = 0.026). Furthermore, 389 (94%) children were diagnosed with allergic rhinitis. Among these patients, 130 (33%) had ADHD symptoms with the following subtypes - predominantly inattentive subtype (13.62%), predominantly hyperactive/impulsive subtype (6.43%) and combined inattention/hyperactivity (13.37%). However, evidence was not sufficient to demonstrate an association between ADHD subtypes and allergic rhinitis severity. Lastly, 206 (50%) children were diagnosed with atopic dermatitis. Among these patients, 71 (34%) had ADHD symptoms with the following subtypes - predominantly inattentive subtype (14.56%), predominantly hyperactive/impulsive subtype (4.85%) and combined inattention/hyperactivity (15.05%). However, there was insufficient evidence to demonstrate a link between ADHD subtypes and atopic dermatitis severity.</p><p style="text-align: justify;"><strong>CONCLUSION:</strong> Children with allergies, especially those with severe asthma, are more likely to have ADHD symptoms.</p>
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Attention Deficit Disorder with Hyperactivity , AsthmaABSTRACT
Air pollution, climate change, and reduced biodiversity are major threats to human health with detrimental effects on a variety of chronic noncommunicable diseases in particular respiratory and cardiovascular diseases. The extent of air pollution both outdoor and indoor air pollution and climate change including global warming is increasing-to alarming proportions particularly in the developing world especially rapidly industrializing countries worldwide. In recent years, Asia has experienced rapid economic growth and a deteriorating environment and increase in allergic diseases to epidemic proportions. Air pollutant levels in many Asian countries especially in China and India are substantially higher than are those in developed countries. Moreover, industrial, traffic-related, and household biomass combustion, indoor pollutants from chemicals and tobacco are major sources of air pollutants, with increasing burden on respiratory allergies. Here we highlight the major components of outdoor and indoor air pollutants and their impacts on respiratory allergies associated with asthma and allergic rhinitis in the Asia-Pacific region. With Asia-Pacific comprising more than half of the world's population there is an urgent need to increase public awareness, highlight targets for interventions, public advocacy and a call to action to policy makers to implement policy changes towards reducing air pollution with interventions at a population-based level.
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Humans , Administrative Personnel , Air Pollutants , Air Pollution , Air Pollution, Indoor , Allergy and Immunology , Asia , Asian People , Asthma , Biodiversity , Biomass , Cardiovascular Diseases , China , Climate Change , Climate , Consumer Advocacy , Developed Countries , Economic Development , Family Characteristics , Global Warming , Hypersensitivity , India , Rhinitis, Allergic , TobaccoABSTRACT
INTRODUCTION: Asthma is a chronic disease of the airways, which is increasing its prevalence among teenagers recently. The trigger-related factors are numerous, including environmental factors, genetic, food among others. OBJECTIVE: Investigate the prevalence of asthma symptoms and possible risk factors in adolescents. METHODS: This is a cross-sectional, descriptive and quantitative study conducted in 104 adolescents aged between 13 to 14 years old of both sexes from four educational institutions: three private and one public. Participants answered two questionnaires: one on risk factors for allergic diseases (EISL) and the other on asthma symptoms (ISAAC asthma module). RESULTS: 104 adolescents answered the questionnaire: 54.8% girls and 45.2% boys. Male subjects had the most active asthma (64%) than female (20%) (p = 0.01) and also had more physician-diagnosed asthma (34.4%) than girls (6.1%) (p = 0.04), more wheezing after exercise (34.4%; 12.1%) (p = 0.03). Regarding the association between the symptoms and the risk factors we observed a statistically significant relationship between the presence of wheezing and hospitalization for public schools girls (p = 0.05). CONCLUSION: There is a higher prevalence of asthma symptoms in males than in females unlike other studies was observed.
INTRODUÇÃO: A asma é a doença crônica das vias aéreas que vem apresentando um aumento na sua prevalência entre os adolescentes nas últimas décadas. Os fatores relacionados com o seu desencadeamento são inúmeros, passando por fatores ambientais, genéticos, alimentares dentre outros. OBJETIVO: Analisar a prevalência dos sintomas da asma e possíveis fatores de risco associados em adolescentes. MÉTODO: Trata-se de um estudo transversal, descritivo e quantitativo realizado em 104 adolescentes de 13 e 14 anos, de ambos os sexos, de quatro instituições de ensino: três privadas e uma pública. Os participantes responderam a dois questionários: um sobre os fatores de risco para doenças alérgicas e o outro sobre os sintomas da asma (ISAAC módulo asma). RESULTADOS: Responderam ao questionário 104 adolescentes: 54,8% meninas e 45,2% meninos. Os voluntários do sexo masculino apresentaram mais asma ativa (64,%) que as voluntárias (20%) (p = 0,01) e também tiveram mais asma diagnosticada (34,4%) do que as voluntárias (6,1%) (p = 0,04), além de mais chiado no peito após exercício (34,4%; 12,1%) (p = 0,03). Com relação à associação entre os sintomas e os fatores de riscos observou-se uma relação estatisticamente significante entre presença de sibilos e hospitalizações para as meninas de escolas públicas (p=0,05). CONCLUSÃO: Houve maior frequência de adolescentes do sexo masculino com asma ativa, asma diagnostica e sibilos após exercício físico. Por outro lado, as meninas da escola pública apresentaram um maior risco de hospitalização na presença de sibilos. Os demais fatores de riscos não apresentaram associações estatisticamente significantes com os sintomas da asma.
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OBJECTIVE: In this study, we evaluated the prevalence of allergic disease in offsprings delivered via the delivery modes of vaginal delivery vs. planned Cesarean section vs. Cesarean section with labor. METHODS: This study included 175 mother-neonate pairs from Severance Hospital who were enrolled in the Cohort for Childhood Origin of Asthma and allergic diseases study. Information regarding prenatal environmental factors, delivery, and diagnosis of allergic diseases was obtained from a questionnaire and medical record review. Patients with at least 3 years of follow-up data were included in this study. Results were adjusted for sex, birth weight, gestational age at birth, season of birth, neonatal intensive care unit admission, parity, breastfeeding, and maternal factors. RESULTS: A total of 175 offsprings were eligible for analysis. Among the subjects, 52.0% were delivered by vaginal delivery, 34.3% by planned Cesarean section, and 16.6% by Cesarean section with labor. Fifty-nine offsprings (33.7%) were diagnosed with allergic disease at a median age of 1 year (range 0.5–3 years). The prevalence of allergic disease was not associated with delivery mode after adjusting for confounding variables. Time period from membrane rupture to delivery, duration of the active phase, and the beginning of the pelvic division prior to Cesarean section were not associated with allergic disease development in offsprings. CONCLUSION: Cesarean section, irrespective of the occurrence of labor before surgery, did not increase the prevalence of allergic disease in infants up to 3 years of age.
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Female , Humans , Infant , Infant, Newborn , Pregnancy , Asthma , Birth Weight , Breast Feeding , Cesarean Section , Cohort Studies , Diagnosis , Follow-Up Studies , Gestational Age , Intensive Care, Neonatal , Medical Records , Membranes , Parity , Parturition , Prevalence , Rupture , SeasonsABSTRACT
Human health is closely related to the intestinal flora. The intestinal flora regulates the body's immune function by promoting the development of the immune system of the intestine, inducing differ-entiation of T cells, and other ways, so that it is in equilibrium, thereby avoiding or reducing the occurrence of immune-related diseases. Allergic diseases are related to incomplete development of the autoimmune system and imperfect immune control mechanisms. Moreover, the distribution and diversity of bacterial flora in chil-dren with allergies are significantly different from those in healthy children. Therefore, allergic diseases are closely related to the functional status of the intestinal flora. This review summarizes the associations and mech-anisms of common childhood allergic diseases, such as food allergies, eczema, asthma, and anaphylactoid purpura with intestinal flora.
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PURPOSE: Allergic diseases have been increasing worldwide over the past few decades. Allergic sensitization is a pivotal risk factor for the development of allergic diseases. The purpose of this study was to examine changes in allergic sensitization patterns of aeroallergens over the last 10 years in children with respiratory allergic diseases. METHODS: We retrospectively reviewed the medical records of 12,848 children under the age of 18 years who received skin prick tests (n=3,852) or serum specific IgE tests (n=8,996) to evaluate sensitization from 2007 to 2016 in a single center, Seoul, Korea. RESULTS: Sensitization rate to house dust mite (Dermatophagoides farinae and Dermatophagoides pteronyssinus) reached a plateau in preschool (28.3%–32.8%) and schoolchildren (45.8%–47.2%). Sensitization rate to animal dander (cat and dog) was increasing from 8.4% to 12.5% in preschool children and from 10.3% to 18.6% in schoolchildren (trend P<0.001 each). In preschool children, tree (birch, oak, and alder; from 3.5% to 6.4%), grass (timothy; from 0.8% to 6.5%), weed (ragweed and mugwort; from 2.8% to 6.9%) pollens and mold (Alternaria; from 2.5% to 6.0%) were also in similar increasing pattern (trend P=0.001, P<0.001, P=0.003, and P<0.001, respectively). Additionally, tree (from 9.0% to 15.2%), grass (from 2.6% to 5.2%) pollens were also in increasing pattern in schoolchildren (trend P<0.001 and P=0.024, respectively). CONCLUSION: Over the past 10 years, sensitization patterns of aeroallergen have been changing in Korean children with allergic diseases. We should pay attention to the changing patterns of allergic sensitization to educate and prevent the allergic disease.
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Animals , Child , Child, Preschool , Humans , Alnus , Artemisia , Dander , Fungi , Immunoglobulin E , Korea , Medical Records , Poaceae , Pollen , Pyroglyphidae , Retrospective Studies , Risk Factors , Seoul , Skin , TreesABSTRACT
Endocrine disruptor chemicals (EDCs) are similar to steroid hormones in molecular structure, and may have steroid-like disrupting effects on the immune system and influence the risk of allergic diseases. For example, bisphenol A (BPA) and triclosan (TCS) are commonly EDCs existing in the environment, and both BPA and TCS are widely added to daily necessities and catering products. Animal experiments found that prenatal BPA exposure may be associated with higher risk of respiratory allergic diseases in offspring. It was also found by a few epidemiological studies that TCS exposure was associated with higher risks of eczema, and allergic disorders in respiratory system and digestive tracts in children. EDCs may increase cytokines and immunoglobulins levels by interrupting the function of helper T cells (Th1/Th2) so as to affect the immune system, which might be associated with allergic reactions. This review mainly focused on the correlation between EDCs (BPA and TCS) and childhood allergic diseases and the underlying mechanisms.
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Isoflavone phytoestrogen,which is one of the biologi-cal flavonoids, has effect on immune system. Previous research has demonstrated that isoflavone phytoestrogens improve allergic symptom via sustaining Th1/Th2 balance, regulating immune cells and increasing the host on the food of the trigger tolerance effects. This review provides information for the effect of isofla-vone phytoestrogens on allergic disease and its mechanism, ho-ping to promote its research and utilization.
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Mast cells are crucial effector cells in allergic reactions,where IgE is the most notably mechanism to trigger their degranulation and release large amounts of allergic mediators.However,IgE is not the only way to stimulate these cells to degranulate.There is a lot of stimuli,such as complement,neuropeptides,cytokines and other inflammatory products,which can directly trigger mast cell degranulation,and cause selective release of mediators.These mediators are closely related to many allergic and inflammatory diseases.The paper will focus on the activation of non-IgE stimulated human mast cells,and describe the allergic and inflammatory diseases briefly,and provide the theoretical basis for clinical detection,diagnosis and treatment.
ABSTRACT
Several epidemiological studies have reported an association between environmental pollution and various health conditions in individuals residing in industrial complexes. To evaluate the effects of pollution from industrial complex on human health, we performed a pooled analysis of environmental epidemiologic monitoring data for residents living near national industrial complexes in Korea. The respiratory and allergic symptoms and the prevalence of acute and chronic diseases, including cancer, were used as the outcome variables for health effects. Multiple logistic regression analysis was used to analyze the relationship between exposure to pollution from industrial complexes and health conditions. After adjusting for age, sex, smoking status, occupational exposure, level of education, and body mass index, the residents near the industrial complexes were found to have more respiratory symptoms, such as cough (odds ratio [OR], 1.18; 95% confidence interval [CI], 1.06 to 1.31) and sputum production (OR, 1.13; 95% CI, 1.03 to 1.24), and symptoms of atopic dermatitis (OR, 1.10; 95% CI, 1.01 to 1.20). Among residents of the industrial complexes, the prevalence of acute eye disorders was approximately 40% higher (OR, 1.39; 95% CI, 1.04 to 1.84) and the prevalence of lung and uterine cancer was 3.45 times and 1.88 times higher, respectively, than those among residents of the control area. This study showed that residents living in the vicinity of industrial complexes have a high risk of acute and chronic diseases including respiratory and allergic conditions. These results can be used as basic objective data for developing health management measures for individuals residing near industrial complexes.
Subject(s)
Humans , Body Mass Index , Chronic Disease , Cough , Dermatitis, Atopic , Education , Employment , Environmental Pollution , Epidemiologic Studies , Epidemiological Monitoring , Korea , Logistic Models , Lung , Prevalence , Smoke , Smoking , Sputum , Uterine NeoplasmsABSTRACT
Several epidemiological studies have reported an association between environmental pollution and various health conditions in individuals residing in industrial complexes. To evaluate the effects of pollution from industrial complex on human health, we performed a pooled analysis of environmental epidemiologic monitoring data for residents living near national industrial complexes in Korea. The respiratory and allergic symptoms and the prevalence of acute and chronic diseases, including cancer, were used as the outcome variables for health effects. Multiple logistic regression analysis was used to analyze the relationship between exposure to pollution from industrial complexes and health conditions. After adjusting for age, sex, smoking status, occupational exposure, level of education, and body mass index, the residents near the industrial complexes were found to have more respiratory symptoms, such as cough (odds ratio [OR], 1.18; 95% confidence interval [CI], 1.06 to 1.31) and sputum production (OR, 1.13; 95% CI, 1.03 to 1.24), and symptoms of atopic dermatitis (OR, 1.10; 95% CI, 1.01 to 1.20). Among residents of the industrial complexes, the prevalence of acute eye disorders was approximately 40% higher (OR, 1.39; 95% CI, 1.04 to 1.84) and the prevalence of lung and uterine cancer was 3.45 times and 1.88 times higher, respectively, than those among residents of the control area. This study showed that residents living in the vicinity of industrial complexes have a high risk of acute and chronic diseases including respiratory and allergic conditions. These results can be used as basic objective data for developing health management measures for individuals residing near industrial complexes.
Subject(s)
Humans , Body Mass Index , Chronic Disease , Cough , Dermatitis, Atopic , Education , Employment , Environmental Pollution , Epidemiologic Studies , Epidemiological Monitoring , Korea , Logistic Models , Lung , Prevalence , Smoke , Smoking , Sputum , Uterine NeoplasmsABSTRACT
A anafilaxia constitui uma reação sistêmica, severa, potencialmente fatal e com importante impacto na qualidade de vida dos pacientes. Recentes estudos mostram aumento da incidência e prevalência da doença. O manejo inicial é baseado nas manifestações clínicas. Os exames complementares são indicados para a investigação do agente desencadeante. A adrenalina, base de seu tratamento, apresenta boa resposta clínica quando devidamente administrada. Com abordagem emergencial, a anafilaxia é tema de necessário domínio entre os clínicos. Esse trabalho tem o objetivo de revisar o diagnóstico e abordagem terapêutica da anafilaxia incluindo os últimos consensos sobre o tema.
Anaphylaxis is a systemic reaction, severe, potentially fatal and with important impact on the quality of life of people affected. Recent studies show increases in incidence and prevalence of the disease. The initial management is based on the clinical manifestations. The complementary examinations are indicated for the investigation of the triggering agent. The adrenaline, the basis of their treatment, presents good clinical response when properly administered. With emergency approach, this disease is the subject of necessary domain between clinicians. This article aims to review to diagnosis and treatment of anaphylaxis including the recent consensus on the topic.